Lexicon - A-Z Guide 2021 S.I. spécifiques sur la peau des microcirculatoire et contribue à l’endurance et des performances, jambes a révélé une augmenta- améliorer la circulation sanguine et un niveau équilibré de stress tion de 19,6 % du niveau d’oxy- et l’oxygénation des muscles. oxydatif. www.pycnogenol.com. ■ gène et une diminution de 11,9 %du niveau de dioxyde de carboneL’extrait d’écorce de pin maritime®français Pycnogenol constitueDr. Franziska Weichmann, Py après une supplémentation en une solution sûre, naturelle et Manager of Scientific Pycnogenol®pendant 6 semaines éprouvée pour le sport, qui offre Communications and (12). Ces résultats indiquent que de multiples avantages tant aux Product Development at Pycnogenol® améliore la perfu- athlètes professionnels comme Horphag Research. sion tissulaire et soutient ainsi aux sportifs amateurs, notam- une activité musculaire aérobie ment la réduction des crampes et durable pendant l’exercice phy- des douleurs musculaires après sique. Dans le cadre d’une étude l’entraînement, l’amélioration de randomisée en double aveugle et contrôlée par placebo, la micro- Références / References circulation au niveau des ongles de 60 patients atteints de coro- (1). Hawley John A, Hargreaves M, Joyner Hypertens Res 30 (9): 775-780 Michael J et al. (2014) Integrative Biology(12). Belcaro G, Cesarone MR, Errichi naropathie a été évaluée en mesu- of Exercise. Cell 159 (4): 738-749 BM et al. (2006) Diabetic ulcers: rant le diamètre des microvais- (2). Kawamura T,Muraoka I (2018) Exercise- microcirculatory improvement and faster seaux (13). Une amélioration de Induced Oxidative Stress and the Effects healing with pycnogenol. Clin Appl of Antioxidant Intake from a Physiological Thromb Hemost 12 (3): 318-323 la microcirculation a été observée Viewpoint. Antioxidants (Basel, (13). Wang S, Tan D, Zhao Y, Gao G, Gao X, Switzerland) 7 (9): 119 Hu L (1999) The effect of Pycnogenol® chez 53,8 % des patients supplé- (3). Pavlovic P (1999) Improved Endurance By on the microcirculation, platelet function mentés en Pycnogenol ,® contre Use Of Antioxidants. European Bulletin of and ischaemic myocardium in patients Drug Research 7 (2): 26-29 with coronary artery diseases. European 34 % seulement chez les patients (4). Vinciguerra G, Belcaro G., Cesarone, Bulletin of Drug Research 7 (2): 19-25 sous placebo. Ce résultat montre M.R., Rohdewald P., Stuard, S., Ricci, A.,(14). Grimm T, Schäfer A,Högger P (2004) Di Renzo A., Hosoi, M., Dugall, M., Ledda, Antioxidant activity and inhibition que la prise de Pycnogenol® ren- A., Cacchio M., Acerbi, G., Fano, F. (2006) of matrix metalloproteinases by Cramps and muscular pain: Prevention metabolites of maritime pine bark extract 269 force le système de perfusion with Pycnogenol® in normal subjects, (pycnogenol). Free Radic Biol Med 36 (6): venous patients, athletes, claudicants and 811-822 in diabetic microangiopathy. Angiology 57(15). Grimm T, Chovanova Z, Muchova J et al. (3): 331-339 (2006) Inhibition of NF-kappaB activation (5). Belcaro G, Cesarone MR, Errichi S et al. and MMP-9 secretion by plasma of (2008) Variations in C-reactive poei , human volunteers after ingestion of plasma free radicals and fibrinogen values maritime pine bark extract (Pycnogenol). in patients with osteoarthritis treated with J Inflamm (Lond) 31 the microcirculation in the fingernails Pycnogenol. Redox Rep 13 (6): 271-276 (16). Schäfer A, Chovanova Z, Muchova J et of 60 patients with coronary artery (6). Farid R, Mirfeizi Z, Mirheidari M et al. al. (2005) Inhibition of COX-1 and COX-2 (2007) Pycnogenol supplementation activity by plasma of human volunteers disease was determined by measuring reduces pain and stiffness and improves after ingestion of French maritime pine physical function in adults with knee bark extract (Pycnogenol). Biomed the diameter of microvessels (13). In osteoarthritis. Nutrition Research 27 (11): Pharmacother 60 (1): 5-9 53.8% of the patients supplemented 692-697 (17). Canali R, Comitato R, Schonlau F (7). Cisar P, Jany R, Waczulikova I et al. (2008)et al. (2009) The anti-inflammatory with Pycnogenol, the microcirculation® Effect of pine bark extract (Pycnogenol) pharmacology of Pycnogenol in was improved, compared to only 34% on symptoms of knee osteoarthritis. humans involves COX-2 and 5-LOX Phytother Res 22 (8): 1087-1092 mRNA expression in leukocytes. Int in patients with placebo treatment. (8). Belcaro G, Cesarone MR, Errichi S et al. Immunopharmacol 9 (10): 1145-1149 This shows that Pycnogenol® (2008) Treatment of osteoarthritis with (18). Marini A, Grether-Beck S, Jaenicke T et Pycnogenol. The SVOS (San Valentino al. (2012) Pycnogenol(R) effects on skin supplementation strengthens the Osteo-arthrosis Study). Evaluation of elasticity and hydration coincide with signs, symptoms, physical performance increased gene expressions of collagen microcirculatory perfusion system and and vascular aspects. Phytother Res 22 type I and hyaluronic acid synthase in (4): 518-523 women. Skin Pharmacol Physiol 25 (2): contributes to an ameliorated blood (9). Vinciguerra G BG, Bonanni E, Cesarone 86-92 flow and improved oxygenation of MR, Rotondi V, Ledda A, Hosoi (19). Mülek M, Seefried L, Genest F et al. (2013) Evaluation of the effects of (2017) Distribution of Constituents and muscles. Pycnogenol French maritime® supplementation with Pycnogenol on Metabolites of Maritime Pine Bark Extract pine bark extract is a safe, natural and fitness in subjects with the Army Physical (Pycnogenol((R))) into Serum, Blood Cells, Fitness Test and in performances of and Synovial Fluid of Patients with Severe evidence-based solution for sports, athletes in the 100-minute triathlon. J Osteoarthritis: A Randomized Controlled Sports Med Phys Fitness 53644-654 Trial. Nutrients 9 (5): which offers multiple benefits for (10). Aldret R BD (2019) A Double-Blind, (20). Gliemann L, Nyberg M,Hellsten Y (2014) both professional athletes and sports Cross-Over Study to Examine the Nitric oxide and reactive oxygen species Effects of Maritime Pine Extract on in limb vascular function: what is the enthusiasts, including reduced post- Exercise Performance and Postexercise effect of physical activity? Free Radical Inflammation, Oxidative Stress, Muscle Research 48 (1): 71-83 workout cramps and muscle soreness, Soreness, and Damage. Journal of (21). Pütter M GK, Würthwein G, Araghi- improves endurance and performance, dietary supplements1-12 Niknam M, Watson RR, Hosseini S, (11). Nishioka K, Hidaka T, Nakamura S et al. Rohdewald P. (1999) Inhibition of and balanced oxidative stress level. (2007) Pycnogenol, French maritime pine smoking-induced platelet aggregation www.pycnogenol.com. ■ bark extract, augments endothelium- by Aspirin and Pycnogenol. Thrombosis dependent vasodilation in humans. Research 55155–161 News on Functional & Health Ingredients \ Special Issue \ A - Z Health Ingredients 2021 \ ■