Indena seminar \ Event - N°64 solutions DANIELE GIAVINI, bactericidal effects associated with probiotics.” MANAGING DIRECTOR OF INDENA In fact, intervention studies on certain quoted “It wasn’t quite by chance that we chose Stresa and the extracts have recently been conducted by Indena, shores of Lake Maggiore to hold our seminar. Located in as recalled by Elisabetta Frattini, Research Project the Italian Piedmont region, Lake Maggiore enjoys a very Manager. Especially Prodigest (artichoke and® particular climate and encloses one of the most beautiful ginger extracts) and Capersome - phytosomes of® Barromean Islands, Isola Bella. This island is fully covered Boswellia extracts. Highly bioavailable and provi- by the Borromeo Palace and its one-of-a-kind Baroque ding a full “bouquet” of triterpenoids, Casperome® garden. Overloaded with beautiful blossoms and a (250 mg/d) was assessed by 71 persons both for dozen of terraces, this garden accommodates a large subjective (abdominal pain) and objective symp- number of botanical species - lemon trees, artichoke, toms. Another study showed that in the presence tea and medicinal plant varieties. On the shore of the of this extract, of bidifobacteria and lactobacilli, the lake, Stresa is home to various species of gardenia and microbiota remained stable during at least three rhododendron. Some of these botanical varieties are closely related to the development of Indena Group. months. Indeed, Indena and Stresa are truly connected.” A possible research pathway: Indena is currently studying the effect of a combination of turmeric extract and Capserome on SIBO.® Andrea Poli, Chairman of the Nutrition Founda- tion of Italy, presented recent data regarding the incidence of dyslipidemia and the potential role Silent inflammation and ageing of nutraceuticals. If basic concepts exist - the role of LDL lipoproteins in atherogenesis; the reconsi- Ageing is characterized, from a biochemical pers- 157 deration of the role of HDL lipoproteins (“simple” pective, by an increase in the blood concentration risk factors in the cause and effect relationship of infl ammation markers, “a phenomenon which is with atherogenesis) -, the nutritional interventions called ‘in ammaging’”, as reminded by Francesco aimed at reducing blood cholesterol levels have a Visioli, Human Nutrition Professor at the University limited effect on LDL, which, note, is the keliiy pd of Padua, Italy. “The in ammatory response is bene- factor for cardiovascular risk. Hence, “physicians cial when chronic, when it is a transitory response must take into account supplementary treatments, to dangerous conditions and supports the reco- including food supplements, if they notice that very mechanisms.” But “silent chronic in amma- LDL cholesterol levels and cardiovascular risk are tion is detrimental toa large numberof tissues and high, while remaining below the levels that require to normal functioning.” Professor Visioli presented a pharmacological treatment.” few possible solutions to “manipulate” this silent Such interventions could reduce the cardiovas- infl ammation via nutritional interventions. Such an cular risk by impacting the “area under the curve” example is Alyvium, a clinically tested supplement, of the relationship between LDL cholesterol and which diminishes mild to moderated symptoms of cardiovascular risk. psoriasis and is formulated with a mixture of vita- In this particular area, Pietro Allegrini, R&D Director mins and olive polyphenols (Editor’s note: Alyvium of Indena, introduced Vazguard, a recently™ received the Readers’FoodSupplementAward des patented phytosome from bergamot. Two new Nutraceuticals Awards2017). Without forgetting molecules were identifi ed out of the 54 present the role of fi sh oils, of hydroxytyrosol, turmeric, compounds. These polyphenol glycosides had of pro- and prebiotics and certain micronutrients never been described previously. A preclinical (most notably polyphenols). The role of turmeric, pharmacokinetic study followed by a double-blind, precisely, for which Indena has developed Meriva,® randomized study showed the effectiveness of a Phytosome extracted from turmeric, as part of® the standardized extract of this bergamot variety a biomimetic approach. A prerequisite for those (Citrus bergamia Risso & Poileau) that grows in interested in a long-term life maintenance approach. Southern Italy, on the modulation of total, LDL and By launching the motto The Life Guardian , Indena™ HDL cholesterol levels, triglycerides and blood made a key element out of its market differentiation sugar levels. strategy. A genuine symbol ■ News on Functional & Health Ingredients \ N°64 \ July - August - September 2018 \ ■