Triterpenes / Triterpènes TECHNICAL ARTICLE 357 après 28 jours, une grande majorité Sandrine BRIATTE VP, Développement des affaires et Notes : des participants ont observé un teint Réglementation plus uniforme (85 %). VP, Business Development & Regulatory Affairs Conclusion Simon CÔTÉ Les triterpènes sont utilisés depuis VP, Recherche & Développement longtemps comme agents thérapeu- VP, Research & Development tiques dans diverses formulations pharmacologiques. Aujourd’hui, TERLYS Terlys offre la possibilité de les utili- ser comme ingrédients actifs pour les industries des cosmétiques et des soins personnels, sans aucun compromis avec les valeurs d’écores- ponsabilité et de développement References durable. L’action multi-mécanistique (1)Patocka, J., 2003. Journal of Applied Biomedicine , de Nixalin™ est un bon exemple : 1, 7-12. cet actif assure un retour complet à (2)Agra, L. et al., 2015. J Dermatol Treat, 26: 465-470. l’homéostasie de la barrière cutanée. (3)Shaker, D. et al., 2019. ScientiaPharmaceutica, Avec une performance élevée et rapide 87, 17. (4)Martini, M., 2003. Éditions médicales internationales, dans la régénération et la réparation 401p. de la peau, c’est un bon soutien pour (5)Farage, M.A., 2019. Front. Med. 6:98. réduire les conséquences des gestes (6)Misery, L.et al., 2016.J. Eur. Acad. Dermatol. barrières répétitifs sur notre peau. ■ Venereol. 30 (1): 2-8. Tr is suitable for sensitive and weake- tions (Figure4) of dry, sensitive, and ned skin. A second clinical study was weakened skin. These results were performed to determine the efficacy on supplemented by those of the clinical irritation relief and redness reduction test mentioned above: after 28 days, a of a Nixalin™ formula versus a placebo vast majority of the participants obser- formula. These in vivo results confirm ved more even skin complexion (85%). the advantage of using it to quickly improve the comfort of irritated skin. Conclusion After 7 days using this formula, skin irritation was significantly relieved, Triterpenes have long been used with improvement of the condition as a therapeutic agent in various reaching 73% (Figure 2). Furthermore, pharmacological formulations. the severity of redness on the skin was Today, Terlys offers the opportunity quickly reduced and improvement was to use triterpenes as active ingredi- clearly visible (Figure 3). A daily use of ents for the cosmetics and personal such a formulation was also shown to care industries, with a commitment to help to reduce skin redness on the long green sustainability. The multi-mecha- term. After 28 days, a vast majority of nistic action of Nixalin™is a good the participants observed a relief of example to provide a complete return redness in the skin (80%) compared to homeostasis of the skin barrier. with the placebo (60%), confirming With high and fast performance in long-term efficacy (Figure 2). skin regeneration and restoration, this active ingredient helps to reduce •Visible effect on skin imperfection the consequences of the repetitive Conducted on 50 volunteers, a consu- barrier gestures on our skin. ■ mer test confirmed the advantage of using Nixalin™ to improve skin texture and to reduce skin imperfec- The global information on cosmetics & fragrances Guide of cosmetic ingredients - 2020