um) has and distributed by Ideactifs, SantEnergy™ Nu (Eriodictyon californic been studied in overweight and obese women. After 3 months, obese women8 lost 2.1 kg on average and weight and body fat loss trends were noticed across the entire cohort. As for microalgae players, Microphyt (AM # 75) is launching a clinical study in the United States with PhaeoSOL™, its active ingredient derived from Phaeodactylum tricornutum titrated in fucoxanthin (2%). Sixty pre-menopausal women will follow an eating plan and exercise program in conjunction with PhaeoSOL™ supplementation for twelve weeks. Weight, body fat (DEXA), waist and hip circumference are among the main evaluation criteria. The ingredient is currently undergoing Novel Food evaluation in Europe but has already been approved by the FDA. Still across the Atlantic and also in the microalgae segment, natural AstaReal astaxanthin (Haematococcus pluvialis) is the subject of a U.S. patent application for its action on the production of Akkermansia in the gut. As for marine ingredients, Novastell provides weight management solutions with its Lecimarine® range. Indeed, naturally concentrated in phospholipid DHA, these herring roe extracts are supported by the benefits of krill oil. Recent results have precisely shown that marine phospholipids reduce weight gain in mice that have undergone a high-fat diet. In addition, the article suggests that marine phospholipids have a beneficial effect on the composition of the gut microbiota... Has the loop been closed? Since the beginning of the year, the weight loss and drainage segment has increased: +7% compared to last year and occupying a higher ranking as on the 7 positionth among promises (Sell Out GERS, January-April 2021 vs 2020). Among the drivers of this growth, gummies increased by a significant +4,060% in weight loss and fat burning entering the Top 10 promises (8position). For satiety, the progressionth is of 216% being placed on the 10 position. A market that exhibits a certainth dynamism and of which the players in the sector are going to make intelligent use. Nutris sensed it when proposing satiety gummies last year. For others, the key to success will come from the synergy of active ingredients (targeting the microbiota, for instance) but also from matching promises by associating, for instance, slimming with the metabolic syndrome. Some of them are already positioning themselves in this niche (Roquette, which has recently published the latest clinical results of Nutriose® on satiety, the glycemic peak and blood pressure, or even Bénéo with its active ingredient Palatinose™ targeting blood9 sugar and the insulinemic response, etc., to name just these latter). On the brand side, Culturelle® (leader in probiotics) is launching in Canada and the United States, its first product targeting both metabolic health and weight. Are we witnessing a multiplication of the targets aimed at freeing the slimming segment from its “aesthetic”issues? A hyper-segmentation—and even personalization—of the offering with better support for consumers? The fact is that weight management is and will remain multi-factorial. And this also the reason why both players and consumers, regardless of their approach, will benefit from it, if and only if backed up by science. • 1Dietary and lifestyle changes during Covid-19 and the subsequent lockdowns among Polish adults: a cross-sectional online survey PLifeCOVID-19 study. M. Gornicka and coll. Nutrients. 2020, Aug 2MP43-Breast milk-dependent associations of infant gut microbiota with childhood BMI z score. M. K. Differding and coll. American Heart Association. May, 21, 2021 3Gut microbia profile and its association with clinical variables and dietary intake in overweight/obese and lean subjects: across-sectional study. J. Companys and coll. Nutrients. 2021, Jun 4A high protein calorie restriction diet alters the gut microbiome in obesity. T. S. Dong and coll. Nutrients. 2020, Oct 5Dysosmobacter wellbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice. T. Le Roy and coll. Gut microbiota. 2021, May 6The probiotic strain H. alvei HA4597 improves weight loss in overweight subjects under moderate hypocaloric diet: a proof-of-concept, multicenter randomized, double-blind placebo-controlled study. P. Déchelotte and coll. Nutrients. 2021, Jun 7Clinic evaluation of Moro (Citrus sinensis (L.) osbeck) orange juice supplementation for the weight management. V. Cardile and coll. Nat Prod Researches. 2015 8A food supplement with antioxidative Santa herba extract modulates energy metabolism and contributes to weight management. Y. Mödinger and coll. Journal of Medicinal Food. 2021, Jul 9Impact of dietary supplementation with resistant dextrin (Nutriose®) on satiety, glycaemia, and related endpoints, in healthy adults. M. R. Hobden and coll. European Journal of Nutrition. 2021, Jun #76 - 151 -GAM s’fitcA