Probiotic-based stress concepts Activ’Inside organised a webinar dedicated to innovation in stress, together with two other companies: the Canadian Lallemand Health Solutions (probiotics) and the Israeli Maabarot (oral strips). Isabelle Champié, Vice-President Sales and Marketing, Lallemand Health Solutions, explains the potential of probiotics in this context. Actif’s Mag: The gut-brain axis under the prism of stress Actif’s Mag: Is it possible to develop oral strips with is relatively new in the probiotics sector. However, probiotics? Lallemand was a pioneer in this field. What prompted you Isabelle Champié: We have not recently studied this galenic to explore this avenue? form specifically. The stability of probiotics is a key element of Isabelle Champié: The founder of Institut Rosell®, Dr Rosell, their quality. Bacteria can be sensitive to humidity and oxygen, had already published a study more than 90 years ago, in 1929, which are two parameters to be studied as a priority. The quan- showing the impact of pathogec fer entation on sleep and tity of probiotics required per dose may also be a barrier to this languor. type of dosage form. In 1998, Institut Rosell® was acquired by Lallemand Inc., which opened the door to new research opportunities focused on the Actif’s Mag: What about concepts combining probiotics scientific and clinical documentation of probiotic formulations and CBD? Does it make sense? Does it already exist? beneficial to human health. Isabelle Champié: This concept emerged a few years ago on In 2008, Cerebiome® (formerly Probio’Stick®) was studied for the North American market. CBD has interesting properties stress-related digestive discomfort. At that time, gastrointesti- but the quantities required to achieve the expected effect re- nal health was the main known effect of probiotics. Following main high and the regulations surrounding this product are this study, our teams studied Cerebiome® in a pre-clinical stress not always clear. On the other hand, the Safr’Inside™ ingre- model which confirmed the effects on the gut but also on the dient has demonstrated specific effects on mood and anxiety brain [Girard, 2009]. In 2010, the first human study demons- and its technical characteristics, such as microencapsulation, trating the effect of a probiotic on stress was published with are compatible with the probiotic strains of Lallemand Health Cerebiome® [Messaoudi, 2010]. Solutions. • Actif’s Mag: Is thisthe first time you have collaborated with an external company? Interview by Philippe Millet Isabelle Champié: Cooperation spells success. Over the years, Lallemand Health Solutions has developed numerous colla- borations with external companies, experts in their fields, in- • Aventus Innovations (Canada) / développement de formes cluding very recent ones with Aventus Innovations, Nimble orales innovantes - development of innovative oral forms Science, Purity-IQ™, and one that dates back a few years with ComboCap. These collaborations bring added value to our • Nimble Science (Canada) / gélule Simba™ de collecte in situ clients and consumers in a controlled and qualitative way, each d’échantillons du microbiote intestinal - Simba™ capsule for in partner being an expert in its field. situcollection of gut microbiota samples • Purity-IQ™ (Canada) / biotechnologies génétiques, chimiques et métabolomiques - genetic, chemical and metabolomic biotechnologies • ComboCap (Etats-Uni) / gélules 2 en 1 avec membrane mobile - 2-in-1 capsules with moving membrane #76 - 331 -GAM s’fitcA