INGREDIENTS: More and more clinical studies From plant extracts (alone or in mixtures) to marine or dairy peptides, active ingredients with effects on stress, sleep or mood, but also sometimes more broadly (nootropics), science continues to support relevant ingredients for effective formulations. Lactium® from theIngredia cooperative group was one of the clinical trial of 100 healthy participants with mild sleep disor- very first ingredients to explore the issue of stress. Isolated inders showed significant improvement in sleep quality and con- the 1990s, this milk protein hydrolysate obtained by tryptic hy-centration, judgment, reaction time. Water soluble, it is suitable drolysis, contains a bioactive decapeptide with relaxing proper-for multiple dosage forms: tablets, capsules, stick-packs, drops, ties, called alpha-casozepine. It has since been the subject of no gummies, shots,liquid applications and functional foods. less than nine clinical studies - while the first ones focused on DailyZzTMmeets the conditions of use of green tea (Camellia the anti-stress effect, the last one (2018) showed an action onsinensis) related to the pending plant claim « Promotes natural sleepiness. In total, no less than 500 volunteers were enrolledsleep/relaxation/concentration ». in the successive studies (doses of 150, 300, 600 mg/day). ItsRobuvit® (Horphag) - a clinical study (91 subjects) based on the mechanism of action is known: the decapeptide binds selec- BMIS (Brief Mood Introspection Scale) questionnaire showed tively to the benzodiazepine sites of the GABA receptors. the significant impact of Robuvit® on their mood. The score of The studies have enabled the authorities in certain countriesthe Robuvit® subject group went from a majority of “unpleas- to grant it health claims - in South Korea for stress and sleep;ant” feelings to a majority of “pleasant” feelings. The ingredient in the USA, no less than seven structure-function claims havealso targets stress, sleep (clinical studies). been accepted depending on the dose used (at 600 mg for the LenHop® is a lipophilic hop flower extract characterized by its reduction and maintenance of cortisol levels in the event of content (at least 15%) of humulones and lupulones. According acute stress; at 150 and 300 mg for sleep); a claim also obtainedto the Italian company Biosfered, which offers it on the mar- in Australia. ket (Unipex in France), the extract is effective against stress and To help market Lactium®, a B2B2C brand, Ingredia offers many participates in sleep by modulating GABA receptors. Two dos- tools. In addition to a dedicated website for consumers, the ages: 300 - 400 mg/day for two weeks for acute phases; 150 - 250 group offers Lactalk on Youtube, “smart” video sessions in mgfor three months for long-term use. which health professionals decipher the mechanisms of stress, the problems of its control, etc. Smart? The testimonies con-In a study conducted by Expansion Consulteam, unvaccinated firm the interest of decapeptide without mentioning its brandFrench nurses (85) undergoing intense stress and fatigue dur- name... ing the COVID-19 pandemic were given a daily dose of 100 mg A recently published study (Schieffler DA, Matta SE. Mil Med.Ubiquinol™ (Kaneka). After 60 days of supplementation, near- 2021) reviewed the preclinical and clinical literature on SAMely two-thirds reported feeling less stressed, and more than half metabolism and the alterations observed in major depres- reported feeling less physically and mentally exhausted. In ad- sive disorders,fatigue, cognition and memory, dementia. dition, more than 7 out of 10 respondents reported improve- Compared to psychotropic medications, SAMe is better accept- ments in their overall well-being. These results are consistent ed by consumers (source: Gnosis by Lesaffre). with previous studies on the anti-fatigue effect of Ubiquinol™. DailyZz™ (Kemin) is a proprietary botanical blend of special- ly selected natural spearmint (Mentha spicata) and green tea INTER: OCEANS AS A SOURCE OF CALM (Camelia sinensis) extracts rich in natural polyphenols (op- Peptidyss® (Abyss Ingredients) is an active ingredient obtained timized ratio of rosmarinic acid and epigallocatechin gallateby enzymatic hydrolysis of sardine co-products and composed (EGCG)).A randomized, double-blind, placebo-controlled of low molecular weight peptides (98% less than 3000 daltons). A preclinical study (in collaboration with Etap-Lab) showed a significant effect of the same level as that obtained with the ydutS esaC — reissoD- 821 -