their effectiveness: the galenic form. The world of stress and will make a smashing entry into this segment of stress and sleep is perhaps the one in which the galenic formulation plays sleep. The lifting of regulatory barriers will open a boulevard the most important role. to “well-being” applications in general, and stress and sleep in particular. For a simple reason: the image conveyed by CBD fits THE GALENIC FORMULATION HAS NOT SAID ITS perfectly with this world of relaxation. Examples in the United LAST WORD States with the recent launches of Charlotte’s Web Calm (10 mg Several brands offer sleep tablets with a differentiated release of CBD full spectrum associated with lemon balm), Gaia Herbs of melatonin: faster in NovaNuit® Triple Action; in two stages Hemp and Herbs Calm (CBD and holy basil, lavender, passion (one fast and one slow) in Nutrissome®. See a differentiated flower). Should we think that the other “active” (plant or not) action of the active ingredients. ArkoRelax® Sommeil Fort with will be doomed to disappear? Probably not. Consumers want fast release of melatonin and slow release of plant extracts naturalness, of course. But also efficiency. The lack of scientific (eschscholtzia, valerian, passiflora). knowledge on CBD in this area are a brake. The brands all Note - still in the sleep segment - the mouth spray. Fleurance wanting to stand out from each other, the premium to science Nature has just launched one recently (two sprays provide 1 mg will be more than ever... • of melatonin). Arkopharma also offers ArkoRelax® Sommeil Flash. Finally, a new galenic has recently been introduced to the stress and sleep supplements market: gummies. In the first half of 2021, sales in pharmacies of sleep supple- ments in the form of gummies have literally exploded: this “sleep” galenic has thus gone from 14 place in 2020 to 1 placestth in 2021, according to the GERS (Sell Out GERS, SellOut data, turnover including VAT January-May 2021 vs 2020). The main contributor to this growth is Procter & Gamble. The group is present in this sleep market with ZzzQuil™ Sleep gummies (me- latonin, vitamin B6, valerian, chamomile, lavender). A coincidence? Not necessarily, because as David Guenoun, founder and president of the Les Miraculeux brand, which has propelled chewinggumes to the forefront and now has two stress and sleep references, explains: “this galenic is recruiting” (see interview). AREAS UNDER EXPLORATION GABA (gamma-amino-butyric acid) is one of the three main + 88 % POUR LES GUMMIES neurotransmitters that act on the brain and moods (40% of neuronal synapses use GABA). This molecule is the main Au 1semestre 2020, les ventes des gummer ies en inhibitory neurotransmitter in the human body. By slowing pharmacies étaient de 6,2 M€. Au 1 semestre 2021, leurser down the stimuli that circulate between the neurons, which are ventes ont atteint près de 12 M€ (11,7 précisément). Soit une then less excited, GABA has a calming and soothing effect (note progression de + 88 % en un an. Le top 10 des promesses that this action of inhibiting nerve impulses has a relaxing effect représentent 96 % des ventes. Outre les gummies pour le on the muscles). For the sake of completeness, many anxiolytic sommeil, ce sont ceux pour la perte de poids, le soin du and antidepressant drugs (e.g. benzodiazepines) act via the visages / beauté et les phanères qui ont le plus progressé modulation of GABA receptors. This molecule is found at the sur la même période (respectivement + 4 000 %, + 2 300 % heart of formulas in which it is associated with plant extracts, et + 750 %). minerals (magnesium in particular), vitamins from the B group (Nutergia is launching ErgyRelax capsules with valerian, eschscholtzia, magnesium, copper and zinc this September in pharmacies). + 88% FOR GUMMIES In the 1 half of 2020, sales of gummies in pharmacies werest THE CBD FUTURE REFEREE? OR TROUBLEMAKER?€6.2M. In the 1 half of 2021, their sales reached nearlyst Faced with formulas in which consumers are often confronted €12M (11.7 precisely). That’s an increase of + 88% in one year. with the same ingredients, the same plants (as a reminde, The top 10 promises represent 96% of sales. In addition to about fifteen plants are waiting for a stress claim and a dozen gummies for sleep, those for weight loss, face/beauty care in sleep, while for digestion, the “candidates” are counted by and skin care have grown the most over the same period several dozen), it is likely that CBD (and all related molecules) (respectively +4,000%, +2,300% and +750%) ydutS esaC — reissoDPEELS/SSERTS- 221 -