du stopper... Elle convient à des inspection machine is a platform thickness, colour, presence of parti- remplissages allant de 2 ml à 1 litre dedicated to lyophilized pharmaceu- culates, glass defects, size and colour et pour des flacons en verre, blanc tical preparations. It combines a pilot of the stopper, crimping guarantee, ou ambré, ou en plastique opaque. « system and a fully automated system integrity, defects and presence of Nous avons beaucoup travaillé notre for the inspection of lyophilized the stopper... It is suitable for filling système de lumière et la largeur injectable drugs. “The problem with containers ranging from 2 ml to 1 litre d’ondes, explique Carlo Marconi, en inspecting this type of products is and for vials made of glass (white or combinant une bonne mécanique, the lack of homogeneity between the amber) or opaque plastic. “We have souple et fiable, et la configuration products or the batches, Carlo Mar- worked a lot on our lighting system optique. Cela a permis une meilleure cono, General Manager BU Inspection and wave length, Carlo Marconi localisation de l’éclairage afin Machines at Antarès Vision says. The explains, by combining reliable and d’éviter les zones d’ombres ». Sur main concern, at production level, is flexible mechanical handling with a cette machine modulaire assurant to avoid the risk of false rejects.” This dedicated optical layout. This allowed 30 000 pièces/heure, on peut new platform offers a global, inno- for a better positioning of the lights in doubler, voire tripler les carrousels vative vision that inspects both the order to avoid shadow areas.” On this pour augmenter les cadences de content and the container from diffe- modular machine with a throughout contrôles. rent angles. The first one involves ins- of 30,000 parts per hour, it’s possible pecting the absence of oxygen inside to double or triple the carousels to LYOCHECK FROM ANTARES the vial using a laser beam. Featuring increase the inspection output rates. VISION: THE NEXT GENERATION the HSGA (head space gas analysis) FOR INSPECTING LYOPHILIZED technology, it tests the sterility of the product by inspecting the integrity PHARMACEUTICAL PREPARA- of the vial. Then all the checkpoints TIONS will be inspected o the vial from a top Introduced at Pharmapack Europe in view, from a bottom view, from a la- Paris, last February, Antarès's novel teral view: geometry, surface and cake specific to the geometry of the case in order in the marketplace when the pharmaceu- concept with tried and tested solutions, to enhance the lyophilization cycle, Pascal tical industry is subject to changes: fewer the packaging and processing industries Sircoulomb explains. This model has been blockbusters produced in several dozens help pharmaceutical companies - whether tested with the industrial scale freeze-driers of millions of units, more targeted, higher proprietary or CMOs/CDMOs - save of the Italian company IMA and the first added-value pharmaceuticals produced time. “We have noted the increasing results are very promising.” in smaller series, as he points out. All of development of integrated systems such these work to our advantage. Pharma- as Ompi’s EZ-Fill with various primary Flexibility and proof ceutical companies are looking for higher packaging suppliers in combination with of concept flexibility on their equipment considering different types of equipment, Vincent Lan- the more frequent batch changeovers. glade confirms. Pharmaceutical companies “For now, ReaDyLyo has mainly seduced Our partnership with Vanrx, who designs need flexible machinery allowing them to molecules under development, as it is more isolators, and with Schott for its adap- achieve various production types (syringes, difficult to modify the primary packaging tiQ platform targeting the automation of vials, cartridges) with different packaging of already existing products, Pascal Sir- their production lines by means of nested suppliers.” coulomb points out. But the new products RTU packaging perfectly illustrates this. that adopted it during their development The same goes for our partnerships with (1) Outlook for global medicines through phase will also keep it during their indus- Dara and Groniger, who develop models 2021, IQVIA MIDAS trial production. As of the second quarter of flexible machines able to process diffe- of 2020, the first commercial batches using rent types of packs (vials or syringes) and (2) Lyophilization in Pharmaceutical RayDyLyo willbe placed on the market in switch from one mode to another quickly Market Forecast 2019-2029, BCC the United States. “Our product stands out and efficiently.” By bringing proof of Research, February 2019 June - 2020 / The Pharmaceutical Post 02 33 KCAP