Monodoses / Single-Doses « La technologie bottlepack est l’une des méthodes de remplissage aseptique les plus sûres » Apparue il y a 50 ans, la technologie Blow-Fill-Seal continue de se développer au sein de l’industrie pharmaceutique en tant que système de production parfaitement éprouvé et parmi les plus sûrs du marché Il y a 50 ans, à quels besoins spécifiques de conditionne- processus sans risque de contami- nation. Chaque processus BFS com- ment venait répondre la tech- mence par l’extrusion d’une paraison nologie BFS ? polymère stérile directement dans le Andreas Häussner, Andreas Häussner : système. Le récipient est ensuite formé, Directeur Marketing Rommelag rempli, scellé et démoulé. Le tout en L’invention du procédé Blow-Fill-Sealune seule opération, dans un système Marketing Director Rommelag (BFS) a permis de produire, remplir fermé et sans intervention extérieure. et sceller des contenants en un seul La logistique complexe et les ”Bottlepack technology one of the safest aseptic filling methods” Appeared 50 years ago, the Blow-Fill-Seal technology continues to develop within the phar- maceutical industry as a highly proven and reliable production system on the market. 50 years ago, what specific All in one operation, in a closed systemlines. This makes bottelpack technology packaging needs were the and without external intervention. one of the safest aseptic filling methods. BFS technology for? Complex logistics and time-consuming cleaning and sterilization processes What major changes has it Andreas Häussner: With the of prefabricated containers are no experienced during these invention of the Blow-Fill-Seal process,longer necessary. The complete fillingfifty years? we were able to produce, fill and paths including the dosing system are seal containers in one single process designed for CIP/SIP. This means that without risk of contamination. Every all product-carrying lines are cleanedA.H: Rommelag improved their BFS process starts with the extrusion by automatically running programs, machines according to customers and of a sterile polymer parison directly sterilized with pressurized steam andalso regulatory requirements in terms in the system. The container is then dried with sterile-filtered air, thisof economic production and product formed, filled, sealed and demoulded. includes also the sterilized of the airsafety. We invented our so called rotary 86 The Pharmaceutical Post 01 / Janvier - 2020