NutraConnect MARKET dardized for a minimum of 10% ported a decrease in weight and forskolin, also stimulates adipose body fat. Anti-atherogenic and tissue burning by increasing anti-inflammatory effects, inclu- cAMP production, as confirmed ding, among others, the regula- by several studies carried out in tion of the lipogenic and lipolytic obese subjects. In one of these genes expression in the liver and studies, after 8 weeks of supple- the improvement of the blood li- mentation (250 mg twice daily), pid profile and glucose tolerance obese women lost 4.5 kg of fat were also reported. In contrast, on average and their fat percen- there is little data available as tage decreased by almost 8% regards the effects on humans. Other studies conducted with L. moduLatIon gasseri SBT2055 report a modest ofthemIcrobIota weight reduction (1kg), presu- mably related to the reduction of abdominal adiposity. Other studies Experimental studies in animals with L. amylovorus only highlight and humans have highlighted the a body fat reduction. In pregnant different composition of the in- women, supplementation with L. testinal microbiota in obese and rhamnosus GG and B. Lactis in slim subjects, but also in diabe- the first trimester of pregnancy re- tics and non-diabetics. The stu- duces blood glucose and insulin dies also noted that changes in levels, and decreases abdominal the composition and/or activity fat accumulation up to 6 months of the microbiota with the aid of after delivery. In obese subjects, probiotics could modulate gene the administration of L. acidophi- expression and host metabolism lus La5, B. lactis Bb12, and L. (in the adipose, muscle and li- casei DN001 in combination with ver tissues, and even satiety), a diet, improves the reduction and thus have an impact on the of the BMI, fat and leptin levels. associated metabolic disorders. Several studies report an impro- The anti-obesity effects of various vement in the diabetic parame- Lactobacillus and Bifidobacteria ters (fasting glucose, cholesterol, were mainly observed in animal glycated haemoglobin ...) after models. Several studies have re- administration of L. acidophilus