22 KEY INGREDIENTS exhibited a significant lower in- with Naticol® exhibited a lower crease in body weight as soon basal glycemia. Also, even if no as the 12th week of treatment effect of the treatment on adipo- whereas no effect of the peptide cyte lipolysis was found, a de- was observed in CD fed mice.. crease of inflammatory cytokines In line with this result, a weaker was retrieved in collagen-sup- increase in fat mass in HFD fed plemented group arguing for a mice supplemented with Nati- potential better insulin sensitivity. col® at both 9 and 18 weeks of Altogether, these results need to be treatment was also observed. completed but are the first descri- In spite of this resistance to obe- bing a beneficial role of warm sea sity promoted by Naticol® treat- fish collagen peptides in a context ment, no difference in glucose of metabolic disease paving the tolerance was found between route for a potential utilization in hu- groups whereas mice treated man obesity-associated disorders.