6 MARKET the subject of several randomized, In addition to these plant-origin ap- double-blind clinical trials showing petite “modulators», marine origin that it is able to improve weight ingredients have also been deve- loss within 8 weeks as compared loped. Such an example is Slimpro, to placebo thanks to its action a blue whiting protein developed on the appetite (-25% calories by the Compagnie des Pêches de consumed) via a 44% increase in Saint-Malo Santé (R&D structure serotonin levels and an increase in of the eponymous company, which leptin levels. Extracted by Sabin- grants this latter access to the re- sa Corp from Garcinia cambogia, source via its fishing vessels). GarCitrin® guarantees a minimum Several studies have been conduc- content of 50% hydroxycitric acid ted: in vitro on intestinal cells mo- in combination with 5% garcinol, dels (involvement in the production which increases its bioavailability of cholecystokinins (CCK) and and therefore its effect on weight glucagon peptide-like 1 (GLP-1), and fat mass loss as well as ap- digestive hormones playing a vital petite suppression as shown in a role in the mechanism of satiety 12-week clinical study comparing and weight management), in vivo the ingestion of Citrin® to that of on an animal model (daily intake Garcitrin® . Another ingredient decreasing the food intake and targeting appetite is Satiereal®, a increasing CCK and GLP-1 plas- natural extract of saffron (Inoreal). ma levels), a randomized, place- bo-controlled, crossover pilot Not only does it act on satiety but study (1 g/day of marine protein also on compulsive eating by acting hydrolysate, significant reduction on serotonin levels. Several rando- in nibbling cravings, lower blood mized placebo-controlled clinical glucose levels without insulin se- studies have demonstrated the ef- cretion), a controlled and rando- ficacy of Satiereal®. The last study, mized efficacy test (120 slightly carried out in 60 women, showed overweight women and men, 1.4 in 8 weeks of supplementation g of Slimpro® half an hour be- (176.5 mg/day) an 84% appetite fore the main meal of the day). suppression and a 78% reduc- tion in sugar cravings and a signi- This latter study showed that the ficant and progressive weight loss subjects consuming Slimpro® (-1kg) as compared to placebo. lost significantly more weight