8 MARKET the field of weight management. Without changing their dietary ha- Capsaicin uses this pathway. bits or physical activity, the sub- The two ingredients contained jects consuming the extract lost by Xanthigen® (fucoxanthin and 9.7% of their abdominal fat and 5 pucinic acid) allow it to also act cm of their waist circumference. on weight by inhibiting adipocyte A second clinical study conduc- differentiation and adipogenic ted in 77 overweight subjects gene expression. Its efficacy (600 showed a 63% reduction of their mg/day) has been tested against excess body fat and a 180 kcal/ placebo in 151 obese women for day increase in their energy ex- 16 weeks: 6.6 kg of weight loss penditure when at rest. Sinetrol® including 4.4 kg of fat and -5.6 cm acts by inhibiting phosphodieste- waist circumference reduction. rase 4, the enzyme which inhibits the degradation of cAMP that LIpIdmetaboLIsm controls the activation of the HSL reguLatIon lipase responsible for lipolysis. HP Ingredient’s CitruSlim™, a blend of flavanone-O-glycosides and Eu- An increase in lipolysis stimulates rypeptides from Eurycoma Longi- the hydrolysis of triglycerides folia, stimulates fat oxidation and and thereby reduces fat storage. inhibits fatty acid synthesis by ac- tivating the AMP kinase pathway. The transcription factors that can stimulate lipolysis are thus targets HP Ingredient has also shown in of interest in the development of clinical studies that CitruSlim™ re- weight management ingredients. duces hepatic steatosis (-46%) as Flavonoids, especially flavonols well as cortisol synthesis – cortisol such as quercetin, can activate li- is a stress hormone. The weight poxygenase and reduce adipoge- loss obtained after 6 weeks of nesis by regulating the AMPK supplementation with 200 mg of pathway. Sinetrol®, a natural ci- CitruSlim™ per day (-2.7 kg as trus extract patented by Fytexia, compared to placebo) is mainly has demonstrated in a rando- due to a fat mass loss (-2.4 kg as mized, double-blind study in 95 compared to placebo). Sabinsa overweight subjects its capacity Corp’s Forslean®, a patented ex- to activate lipolysis over 3 months. tract from Coleus Forskohlii stan-