28 KEY INGREDIENTS after discontinuation of treatment. with Pycnogenol®, whereas it de- Interestingly, no sudden relapse of creased in the control group only pain sensation and symptoms oc- by 1%. This study found a signi- curred. This study again showed ficant decrease of gastrointestinal that patients required significantly complications in the Pycnogenol® less analgesic medication while group, attributed to the lowered supplementing with Pycnogenol® NSAID intake. , whereas this was not the case with In this study the negative impact the placebo-treated control group. of the disease for involvement in social functions including emo- thirdclinicaltrialwith pycnogenol®For Third clinical trial with Pycnogenol® 156 osteoarthritispatients for 156 osteoarthritis patients severe pain start -11% A third clinical trial in Italy investi- moderate gated Pycnogenol® for treatment slight of osteoarthritis in 156 patients. -56% After three months treatment with no pain Pycnogenol® the pain score de- 3 months treatment creased from average 17.3 (maxi- Placebo Pycnogenol® mum possible score of 20 repre- senting severe pain) to 7.7. In the tional aspects was investigated. placebotreated control group the This questionnaire comprises the pain value decreased insignificant- ability to interact with family and ly from mean 17.1 to 15.2. The friends, participate in community stiffness score decreased from events and church attendance. 6.6 (on a scale 0 to 8) to 3.1 and Furthermore, the emotional impact joint physical function decreased including frustration, irritability, lo- from average 55.3 (on a scale 0 neliness and similar aspects was to 68) to 23.8. The control had no investigated. The global score of change of joint stiffness and only these parameters decreased from a marginal improvement of physi- baseline average value 31.4 to cal function. The patient’s conco- 11.5 after three months treatment mitant medication with NSAIDs with Pycnogenol®. This study eva- dropped by 58% during treatment luated the mobility of patients under