FINANCIAL INFORMATION CONCERNING THE GROUP’S ASSETS AND LIABILITIES, FINANCIAL POSITIONAND PROFITS AND LOSSES 20 Note 14: Other income 15.2 General and administrative expenses Other income is detailed in the table below: The table below shows the breakdown of research and development expenses by cost nature for the periods presented: As of December 31, In thousands of euros 2016 2017 As of December 31, Research tax credit (see Note 7) 2,930 3,692 In thousands of euros 2016 2017 Personnel expenses(1) 4,533 5,824 Subsidies 71 10 Total 3,001 3,702 Professional Fees 699 756 Communication and travel 684 897 Note 15: Operating expenses expenses 15.1 Research and development expenses Offices cost 198 288 Equipment rental 21 11 The table below shows the breakdown of general and administrative expenses by cost nature for the periods presented: Office furniture and small 64 68 equipment As of December 31, Postal and telecommunication 84 14 expenses In thousands of euros 2016 2017 (1) Depreciation and amortization 29 40 Personnel expenses 4,375 4,734 expense Sub-contracting, collaboration 11,358 11,672 Attendance fees 86 136 and consultants Insurance 79 56 Licensing and intellectual 1,075 155 property Others 13 86 Offices cost 615 516 Total G&A expenses 6,490 8,173 Travel and entertainment 815 1,065 (1) I ncludes €2,788 K and €3,245 K related to share-based compensation expenses expense as of December 31, 2016 and 2017 respectively. Depreciation and amortization 173 184 15.3 Sales and Marketing expenses expense Other 118 348 The table below shows the breakdown of sales and marketing expenses by cost nature for the periods presented: Total R&D expenses 18,529 18,675 (1) I ncludes €1,847 K and €1,543 K related to share-based compensation As of December 31, expense as of December 31, 2016 and 2017 respectively. In thousands of euros 2016 2017 Personnel expenses(1) 53 — Professional Fees — 627 Communication and travel — 129 expenses Offices cost — 26 Others — 8 Total S&M expenses — 844 (1) Includes €13 K related to share-based compensation expense as of December 31, 2017. 202– GENSIGHT BIOLOGICS – 2017 Registration Document