NutraConnect KEY INGREDIENTS of insulin sensitivity. Both insulin cise, weight loss or adoption resistance and ß - cell dysfunction of a certain diet may reduce are important parameters of T2DM the incidence of T2DM [8,9] . [3] During the pathogenic process In this context, different new ali- . of T2DM, many factors contribute mentation behaviors are consi- to the development of insulin dered such as hypeproteined, resistance and ß - cell dysfunction gluten-free or collagen pep- including genetic, environmental, tides-enriched diets (collagen is and individual behavioral factors, the major structural protein pre- such as overweight, sedenta- sent in skins and bones of all ani- rily, hypertension, and stress. mals where it accounts for 30% of the total protein content [10]). T2DM is believed to be asso- In this aim, this study conducted ciated with obesity, considered with INSERM I2MC Toulouse eva- luates the potential effects of warm sea fish collagen peptides (Nati- col®) on representative metabo- lic and inflammatory parameters. For that, male C57Bl6/J mice fed with either a chow-(CD) or high fat-diet (HFD) were submitted or not to specific collagen peptides in drink water (Naticol®-2 kDa, 4 g/kg bw/d) for 20 weeks. Weight, body composition, glucose to- lerance and insulin sensitivity were followed up. Effects of to be caused by unhealthy eating Naticol® on various blood pa- habits and lifestyle patterns [4,5] rameters reflecting the metabo- . A large number of studies have lism status were also measured reported the strong relationship (free fatty acids, triglycerides, between obesity/overweight and cholesterol, hormones) together the onset of type 2 diabetes [6,7] with adipocyte inflammation. . Conversely, they have shown Results showed that HFD fed that increased physical exer- mice supplemented by Naticol®