2,000+peer-reviewed publications since2003 FibroScan benefits from a unique clinical legitimacy worldwide and is recommended in the guidelines of leading organizations EASL – ALEH 2015 AGA 2017 [2] “ TE can be considered the non-invasive standard “ Vibration-controlled transient elastography (VCTE) for the measurementof liver stiffness.” is the most commonly used imaging-based fibrosis “ For chronic hepatitis C (CHC), it is proposed to associate assessment method in theUnited States.” TE with a blood test (BT), and to accept the diagnosis if “ It has been validated in large cohorts worldwide in both are in agreement.” a spectrum of liver diseases, including hepatitis B, “ TE is a fast, simple, safe and easy to learn procedure hepatitis C, fatty liver disease and autoimmune liver that is widely available. ” disorders, among others.” “ TE can be considered the non-invasive standard for the measurement of LS. ” BAVENO VI 2015 [3] AASLD 2017 [4] “ The introduction of Transient Elastography (TE) in clinical “ There should be a high index of suspicion for NAFLD practice has allowed the early identification of patients and NASH in patients with type 2 diabetes. Clinical with chronic liver disease (CLD) at risk of developing decision aids such as NAFLD Fibrosis Score or FIB4 clinically significant portal hypertension (CSPH) “ or vibration controlled transient elastography (VCTE) can “ Liver Stiffness by TE is sufficient to suspect cACLD be used to identify those at low or high risk for advanced (compensated advanced chronic liver disease) in fibrosis (bridging fibrosis or cirrhosis).” asymptomatic subjects with known causes of CLD (chronic liver disease) “. Peer-reviewed publications per etiology Floollow u p Nono-n-erleltaetded Biliialiray d isieasese Transnpslpalnatnt fo if inetrervetnitinosns livlieve r idsiseaesses 1.7. 7% 2.7. 7% 5 % .95. 5 % NALFDL//NASH Generarla p opulaltioin Daibaebeetses 3.5. 5% OtOhtersrs Genrera l 49% 4.9. 9% poplulaition Pediaitricriscs .7. 5 % 4.5. 5% VCTE Chronoinci H CVC Treaetamenet 212 1% monointoitroinign TRANSIENT ELASTOGRAPHYVIBRATION CONTROLLED iVrirla Hl eHpeaptaittiistis 12.5. % 1.2. 5 % NAFLD/N/ASAHSH Chronoinci H BVB 12.5. % 141 4% Cirirrhohsoissi s lAlcoohloiclic complicliatiotinosns Otehrers livlieve r idsiseaesses & p rporgnosoissi s Alclocholicli li vliere dr idsiesaesae Coinifecetcioino 1.05. 5 % 6 6 % 15.5. % 2.5. % 7.7. 7% [1] Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis [2] American Gastroenterological Association Institute Guideline on the Role of Elastography in the Evaluation of Liver Fibrosis [3] Management of Cirrhosis and portal hypertension FibroScan VCTE has become the “standard” method to better diagnose chronic advanced liver disease, with recommended diagnostic cut-offs in kPa [4] The Diagnosis and Management of Nonalcoholic Fatty Liver Disease: Practice Guidance from the American Association for the Study of Liver Diseases